Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy.

doi:10.1007/BF02740673

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Article

Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy.

Molecular neurobiology - 1 Jan 2000

Tuszynski M H, Gage F H

Abstract excerpt

Multiple genetic and epigenetic events determine neuronal phenotype during nervous system development. After the mature mammalian neuronal phenotype has been determined it is usually static for the remainder of life, unless an injury or degenerative event occurs. Injured neurons may suffer one of three potential fates: death, persistent atrophy, or recovery. The ability of an injured adult neuron to recover from...

Topics

Animals
Brain Injuries
Brain Tissue Transplantation
Cells, Cultured
Cholinergic Fibers
Combined Modality Therapy
Fetal Tissue Transplantation
Fibroblasts
Genetic Therapy
Growth Substances
Hippocampus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macaca fascicularis

Macaca mulatta

Nerve Growth Factors

Nerve Regeneration

Neurons

Phenotype

Rats

Source

Open in PubMed

Identifiers

PMID: 7576305
DOI: 10.1007/BF02740673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7576305-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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