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Article

Further characterization of the effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on axotomized neonatal and adult mammalian motor neurons.

The Journal of comparative neurology - 1 Apr 1994

Clatterbuck R E, Price D L, Koliatsos V E

Abstract excerpt

Neurotrophins and neural cytokines are two broad classes of neurotrophic factors. It has been reported that ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) prevent the degeneration of axotomized neonatal motor neurons. In addition, BDNF is transported retrogradely to alpha-motor neurons following injection into the muscle, and patterns of BDNF expressed in spinal cord and muscle...

Topics

Acetylcholinesterase
Aging
Animals
Animals, Newborn
Axonal Transport
Axons
Brain-Derived Neurotrophic Factor
Choline O-Acetyltransferase
Ciliary Neurotrophic Factor
Denervation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

Male

Microscopy, Electron

Motor Neurons

Nerve Degeneration

Nerve Growth Factors

Nerve Tissue Proteins

Phenotype

Source

Identifiers

PMID: 7515907
DOI: 10.1002/cne.903420106

Genes

BDNF
CNTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7515907-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Further characterization of the effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on axotomized neonatal and adult mammalian motor neurons.PMID 7515907Read ↗

Distinct neurotrophic responses of axotomized motor neurons to BDNF and CNTF in adult rats.Semantic proximity Read ↗

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The neurotrophins BDNF, NT-3 and NT-4/5, but not NGF, up-regulate the cholinergic phenotype of developing motor neurons.Semantic proximity Read ↗

Neurotrophism without neurotropism: BDNF promotes survival but not growth of lesioned corticospinal neurons.Semantic proximity Read ↗

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p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain.Semantic proximity Read ↗

Axotomized septal cholinergic neurons rescued by nerve growth factor or neurotrophin-4/5 fail to express the inducible transcription factor c-Jun.Semantic proximity Read ↗

The role of p75NTR in modulating neurotrophin survival effects in developing motoneurons.Semantic proximity Read ↗

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GDNF gene delivery to injured adult CNS motor neurons promotes axonal growth, expression of the trophic neuropeptide CGRP, and cellular protection.Semantic proximity Read ↗

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