Immune escape from a graft-versus-leukemia effect may play a role in the relapse of myeloid leukemias following allogeneic bone marrow transplantation.

doi:10.1038/sj.bmt.1700778

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Article

Immune escape from a graft-versus-leukemia effect may play a role in the relapse of myeloid leukemias following allogeneic bone marrow transplantation.

Bone marrow transplantation - 1 May 1997

Dermime S, Mavroudis D, Jiang Y Z, Hensel N, Molldrem J, Barrett A J

Abstract excerpt

We studied patients relapsing with myeloid leukemias following allogeneic bone marrow transplantation (BMT) for evidence of immune escape by clonal evolution of the leukemia. Relapsed cells from four out of five patients had a reduced ability to stimulate proliferation of lymphocytes from an HLA-mismatched responder. There was decreased susceptibility to lysis by CTL in three and reduced susceptibility to...

Topics

Adolescent
Adult
Bone Marrow Transplantation
Cytotoxicity, Immunologic
Female
Graft vs Host Reaction
HLA Antigens
Humans
In Vitro Techniques
Killer Cells, Natural
Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Myeloid

Leukemia, Myeloid, Acute

Lymphocyte Activation

Male

Middle Aged

Myelodysplastic Syndromes

Phenotype

Source

Open in PubMed

Identifiers

PMID: 9169643
DOI: 10.1038/sj.bmt.1700778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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