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Article

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation

31 Oct 2018

Abstract excerpt

BACKGROUND: As consolidation therapy for acute myeloid leukemia (AML), allogeneic hematopoietic stem-cell transplantation provides a benefit in part by means of an immune-mediated graft-versus-leukemia effect. We hypothesized that the immune-mediated selective pressure imposed by allogeneic transplantation may cause distinct patterns of tumor evolution in relapsed disease. METHODS: We performed enhanced exome...

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Identifiers

PMID: 30380364
DOI: 10.1056/nejmoa1808777

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