Loss of Mismatched HLA on the Leukemic Blasts of Patients With Relapsed Lymphoid Malignancies Following Bone Marrow Transplantation From Related Donors With HLA Class II Mismatches in the Graft Versus Host Direction.

doi:10.1002/pbc.25819

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Article

Loss of Mismatched HLA on the Leukemic Blasts of Patients With Relapsed Lymphoid Malignancies Following Bone Marrow Transplantation From Related Donors With HLA Class II Mismatches in the Graft Versus Host Direction.

Pediatric blood & cancer - 1 Apr 2016

Hirabayashi Koichi, Kurata Takashi, Horiuchi Kazuki, Saito Shoji, Shigemura Tomonari, Tanaka Miyuki, Yanagisawa Ryu, Matsuda Kazuyuki, Sakashita Kazuo, Koike Kenichi, Nakazawa Yozo

Abstract excerpt

Mechanisms of relapse of acute lymphoblastic leukemia (ALL) after human leukocyte antigen (HLA) class II mismatched hematopoietic stem cell transplantation (HSCT) remain unclear. We report two children with relapsed ALL after HSCT from related donors with HLA-DRB1 and -DQB1 mismatches in the graft versus host direction. One lost HLA-DRB1, DQB1, and DPB1 alleles, and the other lost one HLA haplotype of the...

Topics

Alleles
Child
Female
Graft vs Host Disease
HLA-DP beta-Chains
HLA-DQ beta-Chains
HLA-DRB1 Chains
Haplotypes
Hematopoietic Stem Cell Transplantation
Histocompatibility
Histocompatibility Antigens Class II
Humans

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant

Male

Neoplasm Recurrence, Local

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed

Identifiers

PMID: 26544669
DOI: 10.1002/pbc.25819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.