Article
Loss of Mismatched HLA on the Leukemic Blasts of Patients With Relapsed Lymphoid Malignancies Following Bone Marrow Transplantation From Related Donors With HLA Class II Mismatches in the Graft Versus Host Direction.
Pediatric blood & cancer - 1 Apr 2016
Hirabayashi Koichi, Kurata Takashi, Horiuchi Kazuki, Saito Shoji, Shigemura Tomonari, Tanaka Miyuki, Yanagisawa Ryu, Matsuda Kazuyuki, Sakashita Kazuo, Koike Kenichi, Nakazawa Yozo
Abstract excerpt
Mechanisms of relapse of acute lymphoblastic leukemia (ALL) after human leukocyte antigen (HLA) class II mismatched hematopoietic stem cell transplantation (HSCT) remain unclear. We report two children with relapsed ALL after HSCT from related donors with HLA-DRB1 and -DQB1 mismatches in the graft versus host direction. One lost HLA-DRB1, DQB1, and DPB1 alleles, and the other lost one HLA haplotype of the...
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