Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MRD detection of leukemia relapse using HLA typing by FACS in combination with FISH after mismatched allogeneic stem cell transplantation.

Pediatric transplantation - 1 Aug 2014

Miyachi Mitsuru, Watanabe Eri, Watanabe Nobukazu, Tsuma Yusuke, Kawashima-Goto Sachiko, Tamura Shinichi, Imamura Toshihiko, Ishida Hiroyuki, Hosoi Hajime

Abstract excerpt

Loss of mismatched HLA is a cause of relapse following HLA-mismatched allo-SCT. We directly detected the loss of mismatched HLA alleles in relapsed leukemic cells at a MRD level using HLA typing by multicolor FACS (HLA-Flow) in combination with FISH in the BM of two patients with MLL-AF9-positive AML, at 6 and 10 months after mismatched allo-SCT. HLA-Flow with FISH analysis detected relapsed leukemic cells not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Separation
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histocompatibility Testing

Share to HLA Antigens

Share to Leukemia, Myeloid, Acute

Share to Neoplasm Recurrence, Local

Share to Neoplasm, Residual

Share to Transplantation, Homologous

Source

Identifiers

PMID: 24813938
DOI: 10.1111/petr.12267

Genes

SCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MRD detection of leukemia relapse using HLA typing by FACS in combination with FISH after mismatched allogeneic stem cell transplantation.PMID 24813938Read ↗

Immune Escape of Relapsed AML Cells after Allogeneic TransplantationSemantic proximity Read ↗

Recipient-derived cells after cord blood transplantation: dynamics elucidated by multicolor FACS, reflecting graft failure and relapse.Semantic proximity Read ↗

Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantationSemantic proximity Read ↗

Expansion, persistence and efficacy of donor memory-like NK cells for the treatment of post-transplant relapseSemantic proximity Read ↗

Incidence, risk factors and clinical outcome of leukemia relapses with loss of the mismatched HLA after partially incompatible hematopoietic stem cell transplantation.Semantic proximity Read ↗

Identification and surveillance of rare relapse-initiating stem cells during complete remission after transplantationSemantic proximity Read ↗

Genome-wide Profiling in AML Patients Relapsing after Allogeneic Hematopoietic Cell TransplantationSemantic proximity Read ↗

Pre-emptive Detection and Evolution of Relapse in Acute Myeloid Leukemia by Flow Cytometric Measurable Residual Disease SurveillanceSemantic proximity Read ↗

Postallogeneic monitoring with molecular markers detected by pretransplant next-generation or Sanger sequencing predicts clinical relapse in patients with myelodysplastic/myeloproliferative neoplasms.Semantic proximity Read ↗

Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantationSemantic proximity Read ↗

Downregulation of HLA class II is associated with relapse after allogeneic stem cell transplantation and alters recognition by antigen-specific T cells.Semantic proximity Read ↗

Loss of mismatched HLA in leukemia after stem-cell transplantation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.