Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains.

doi:10.1172/JCI119445

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Article

Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains.

The Journal of clinical investigation - 1 Jun 1997

Lukomski S, Sreevatsan S, Amberg C, Reichardt W, Woischnik M, Podbielski A, Musser J M

Abstract excerpt

Cysteine proteases have been implicated as important virulence factors in a wide range of prokaryotic and eukaryotic pathogens, but little direct evidence has been presented to support this notion. Virtually all strains of the human bacterial pathogen Streptococcus pyogenes express a highly conse...

Topics

Animals
Cysteine Endopeptidases
Humans
Male
Mice
Mutagenesis
Mutation
Plasmids
Streptococcal Infections
Streptococcus pyogenes
Virulence

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