Article
A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin.
Microbial pathogenesis - 1 Nov 1993
Kapur V, Topouzis S, Majesky M W, Li L L, Hamrick M R, Hamill R J, Patti J M, Musser J M
Abstract excerpt
Streptococcus pyogenes secretes an extracellular cysteine protease that cleaves human interleukin 1 beta precursor to form biologically active IL-1 beta, a major cytokine mediating inflammation and shock. To further investigate the potential role of the cysteine protease in host-parasite interactions, the enzyme was purified to apparent homogeneity and tested for ability to degrade several human extracellular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.