A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin.

doi:10.1006/mpat.1993.1083

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Article

A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin.

Microbial pathogenesis - 1 Nov 1993

Kapur V, Topouzis S, Majesky M W, Li L L, Hamrick M R, Hamill R J, Patti J M, Musser J M

Abstract excerpt

Streptococcus pyogenes secretes an extracellular cysteine protease that cleaves human interleukin 1 beta precursor to form biologically active IL-1 beta, a major cytokine mediating inflammation and shock. To further investigate the potential role of the cysteine protease in host-parasite interact...

Topics

Alleles
Bacterial Proteins
Base Sequence
Cells, Cultured
Codon
Cysteine Endopeptidases
Endothelium, Vascular
Extracellular Matrix
Fibronectins
Genes, Bacterial
Glycoproteins
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Phylogeny

Point Mutation

Sequence Alignment

Sequence Deletion

Sequence Homology, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 7516997
DOI: 10.1006/mpat.1993.1083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7516997-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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