Article
Genetic inactivation of the extracellular cysteine protease enhances in vitro internalization of group A streptococci by human epithelial and endothelial cells.
Microbial pathogenesis - 1 Jun 1998
Burns E H, Lukomski S, Rurangirwa J, Podbielski A, Musser J M
Abstract excerpt
Group A Streptococcus (GAS) produces an extracellular cysteine protease (streptococcal pyrogenic exotoxin B) that participates in virulence. We examined two pairs of isogenic GAS strains (serotype M2 and M3) for ability to be internalized by human umbilical vein endothelial cells and A549 human l...
Topics
- Bacterial Proteins
- Cell Line
- Endothelium, Vascular
- Epithelial Cells
- Exotoxins
- Fibroblasts
- Genes, Bacterial
- Humans
- Lung
- Membrane Proteins
- Mutation
- Phagocytosis
- Streptococcus pyogenes