Article
Genetic inactivation of the extracellular cysteine protease enhances in vitro internalization of group A streptococci by human epithelial and endothelial cells.
Microbial pathogenesis - 1 Jun 1998
Burns E H, Lukomski S, Rurangirwa J, Podbielski A, Musser J M
Abstract excerpt
Group A Streptococcus (GAS) produces an extracellular cysteine protease (streptococcal pyrogenic exotoxin B) that participates in virulence. We examined two pairs of isogenic GAS strains (serotype M2 and M3) for ability to be internalized by human umbilical vein endothelial cells and A549 human lung fibroblasts. For both host cell types, the level of internalization by the cysteine protease-negative mutant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.