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Article

Role of streptococcal pyrogenic exotoxin B in the mouse model of group A streptococcal infection.

Infection and immunity - 1 Aug 1998

Kuo C F, Wu J J, Lin K Y, Tsai P J, Lee S C, Jin Y T, Lei H Y, Lin Y S

Abstract excerpt

Streptococcal pyrogenic exotoxin B (SPE B) is a cysteine protease produced by Streptococcus pyogenes. In this study, the differences in virulence between protease-positive clinical isolates and their protease-negative mutants were examined in a mouse model. Isogenic protease-negative mutants were constructed by homologous recombination, using integrational plasmids to disrupt the speB gene. These mutants caused...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9673282
DOI: 10.1128/IAI.66.8.3931-3935.1998
PMCID: PMC108455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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