Article
Role of streptococcal pyrogenic exotoxin B in the mouse model of group A streptococcal infection.
Infection and immunity - 1 Aug 1998
Kuo C F, Wu J J, Lin K Y, Tsai P J, Lee S C, Jin Y T, Lei H Y, Lin Y S
Abstract excerpt
Streptococcal pyrogenic exotoxin B (SPE B) is a cysteine protease produced by Streptococcus pyogenes. In this study, the differences in virulence between protease-positive clinical isolates and their protease-negative mutants were examined in a mouse model. Isogenic protease-negative mutants were...
Topics
- Animals
- Bacterial Proteins
- Cysteine Endopeptidases
- Disease Models, Animal
- Exotoxins
- Immunization, Passive
- Membrane Proteins
- Mice
- Mice, Inbred BALB C
- Mutation
- Rabbits
- Streptococcal Infections
- Streptococcus pyogenes
- Vaccination
- Virulence