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Article

Genetic modifiers of Leprfa associated with variability in insulin production and susceptibility to NIDDM.

Genomics - 1 May 1997

Chung W K, Zheng M, Chua M, Kershaw E, Power-Kehoe L, Tsuji M, Wu-Peng X S, Williams J, Chua S C, Leibel R L

Abstract excerpt

In an attempt to identify the genetic basis for susceptibility to non-insulin-dependent diabetes mellitus within the context of obesity, we generated 401 genetically obese Leprfa/Leprfa F2 WKY13M intercross rats that demonstrated wide variation in multiple phenotypic measures related to diabetes, including plasma glucose concentration, percentage of glycosylated hemoglobin, plasma insulin concentration, and...

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PMID: 9169130
DOI: 10.1006/geno.1997.4672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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