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Article

Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats.

Physiological genomics - 1 Nov 2012

Solberg Woods Leah C, Holl Katie L, Oreper Daniel, Xie Yuying, Tsaih Shirng-Wern, Valdar William

Abstract excerpt

Type 2 diabetes (T2D) is a disease of relative insulin deficiency resulting from both insulin resistance and beta cell failure. We have previously used heterogeneous stock (HS) rats to fine-map a locus for glucose tolerance. We show here that glucose intolerance in the founder strains of the HS colony is mediated by different mechanisms: insulin resistance in WKY and an insulin secretion defect in ACI, and we...

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Share to Chromosomes, Mammalian
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose

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Share to Rats, Inbred WKY

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Identifiers

PMID: 22947656
DOI: 10.1152/physiolgenomics.00040.2012
PMCID: PMC3524769

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