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Article

Escape mutants of HIV-1 proteinase: enzymic efficiency and susceptibility to inhibition.

Biochimica et biophysica acta - 25 Apr 1997

Wilson S I, Phylip L H, Mills J S, Gulnik S V, Erickson J W, Dunn B M, Kay J

Abstract excerpt

Genes encoding a number of mutants of HIV-1 proteinase were sub-cloned and expressed in E. coli. The proteinases containing mutations of single residues (e.g., G48V, V82F, I84V and L90M) were purified and their catalytic efficiencies relative to that of wild-type proteinase were examined using a polyprotein (recombinant HIV-1 gag) substrate and several series of synthetic peptides based on the -Hydrophobic *...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9165106
DOI: 10.1016/s0167-4838(96)00224-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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