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Article

Resistance to HIV protease inhibitors: a comparison of enzyme inhibition and antiviral potency.

Biochemistry - 16 Jun 1998

Klabe R M, Bacheler L T, Ala P J, Erickson-Viitanen S, Meek J L

Abstract excerpt

Resistance of HIV-1 to protease inhibitors has been associated with changes at residues Val82 and Ile84 of HIV-1 protease (HIV PR). Using both an enzyme assay with a peptide substrate and a cell-based infectivity assay, we examined the correlation between the inhibition constants for enzyme activity (Ki values) and viral replication (IC90 values) for 5 active site mutants and 19 protease inhibitors. Four of the...

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Identifiers

PMID: 9628735
DOI: 10.1021/bi972555l

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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