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Article

Kinetic characterization of human immunodeficiency virus type-1 protease-resistant variants.

The Journal of biological chemistry - 26 Jul 1996

Pazhanisamy S, Stuver C M, Cullinan A B, Margolin N, Rao B G, Livingston D J

Abstract excerpt

Passage of human immunodeficiency virus type-1 (HIV-1) in T-lymphocyte cell lines in the presence of increasing concentrations of the hydroxylethylamino sulfonamide inhibitor VX-478 or VB-11328 results in sequential accumulation of mutations in HIV-1 protease. We have characterized recombinant HIV-1 proteases that contain these mutations either individually (L10F, M46I, I47V, I50V) or in combination (the double...

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PMID: 8663409
DOI: 10.1074/jbc.271.30.17979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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