Kinetic characterization of human immunodeficiency virus type-1 protease-resistant variants.

doi:10.1074/jbc.271.30.17979

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Article

Kinetic characterization of human immunodeficiency virus type-1 protease-resistant variants.

The Journal of biological chemistry - 26 Jul 1996

Pazhanisamy S, Stuver C M, Cullinan A B, Margolin N, Rao B G, Livingston D J

Abstract excerpt

Passage of human immunodeficiency virus type-1 (HIV-1) in T-lymphocyte cell lines in the presence of increasing concentrations of the hydroxylethylamino sulfonamide inhibitor VX-478 or VB-11328 results in sequential accumulation of mutations in HIV-1 protease. We have characterized recombinant HI...

Topics

Amino Acid Sequence
Binding Sites
Carbamates
Furans
Genetic Variation
HIV Protease
HIV Protease Inhibitors
HIV-1
Hydrolysis
Indinavir
Isoquinolines
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Molecular Sequence Data

Mutation

Oligopeptides

Pyridines

Quinolines

Source

Open in PubMed

Identifiers

PMID: 8663409
DOI: 10.1074/jbc.271.30.17979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8663409-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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