Article
Analysis of resistance to human immunodeficiency virus type 1 protease inhibitors by using matched bacterial expression and proviral infection vectors.
Journal of virology - 1 Sept 1995
Maschera B, Furfine E, Blair E D
Abstract excerpt
There are already reports, from clinical trials with human immunodeficiency virus type 1 protease inhibitors, of the emergence of drug-resistant mutants which have one or more point mutations in their protease genes. To examine roles of individual and multiple amino acid substitutions in terms of...
Topics
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- DNA Primers
- Drug Resistance, Microbial
- Escherichia coli
- Genetic Variation
- Genetic Vectors
- HIV Protease
- HIV Protease Inhibitors
- Interferon-gamma
- Kinetics
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Point Mutation
- Polymerase Chain Reaction
- Proviruses
- Recombinant Proteins