Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV protease: enzyme function and drug resistance.

Vitamins and hormones - 1 Jan 2000

Gulnik S, Erickson J W, Xie D

Abstract excerpt

HIV protease is responsible for processing of the gag and gag-pol polyproteins during virion maturation. The activity of this enzyme is essential for virus infectivity, rendering the protein a major therapeutic target for AIDS treatment. This articles reviews the biochemical and biophysical properties of the enzyme. The clinical and in vitro observations of resistance to protease inhibitors are discussed from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Microbial
Share to HIV
Share to Binding Sites

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dimerization

Share to HIV Protease

Share to HIV Protease Inhibitors

Share to Substrate Specificity

Share to Thermodynamics

Source

Identifiers

PMID: 10668400
DOI: 10.1016/s0083-6729(00)58026-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV protease: enzyme function and drug resistance.PMID 10668400Read ↗

HIV Protease: Historical Perspective and Current ResearchSemantic proximity Read ↗

Comprehending the Structure, Dynamics, and Mechanism of Action of Drug-Resistant HIV ProteaseSemantic proximity Read ↗

HIV-1 Protease: Structural Perspectives on Drug ResistanceSemantic proximity Read ↗

Characterization of HIV-1 protease mutants: random, directed, selected.Semantic proximity Read ↗

Current and Novel Inhibitors of HIV ProteaseSemantic proximity Read ↗

Navigating HIV-1 drug resistance: A comprehensive review of protease inhibitor efficacy and mutation dynamics.Semantic proximity Read ↗

HIV protease mutations leading to reduced inhibitor susceptibility.Semantic proximity Read ↗

Structural and dynamical aspects of HIV-1 protease and its role in drug resistance.Semantic proximity Read ↗

Action of Anti-HIV Drugs and Resistance: Reverse Transcriptase Inhibitors and Protease InhibitorsSemantic proximity Read ↗

Protease inhibitor resistance in HIV-infected patients: Molecular and clinical perspectivesSemantic proximity Read ↗

Elasticity-Associated Functionality and Inhibition of the HIV Protease.Semantic proximity Read ↗

HIV-1 protease inhibitors: effects on HIV-2 replication and resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.