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Article

Combining mutations in HIV-1 protease to understand mechanisms of resistance.

Proteins - 1 Jul 2002

Mahalingam Bhuvaneshwari, Boross Peter, Wang Yuan-Fang, Louis John M, Fischer Christopher C, Tozser Jozsef, Harrison Robert W, Weber Irene T

Abstract excerpt

HIV-1 develops resistance to protease inhibitors predominantly by selecting mutations in the protease gene. Studies of resistant mutants of HIV-1 protease with single amino acid substitutions have shown a range of independent effects on specificity, inhibition, and stability. Four double mutants, K45I/L90M, K45I/V82S, D30N/V82S, and N88D/L90M were selected for analysis on the basis of observations of increased or...

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Identifiers

PMID: 12012342
DOI: 10.1002/prot.10140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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