Article
Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro 31-8959.
Virology - 10 Jan 1995
Jacobsen H, Yasargil K, Winslow D L, Craig J C, Kröhn A, Duncan I B, Mous J
Abstract excerpt
A human immunodeficiency virus type 1 (HIV-1) variant with highly reduced susceptibility to Ro 31-8959, an inhibitor of the viral proteinase, has been selected by repeated passage of wild-type virus in CEM cells in the presence of increasing concentrations of the inhibitor. Peptide sequences of t...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Line
- DNA Primers
- Drug Resistance, Microbial
- HIV Protease
- HIV Protease Inhibitors
- HIV-1
- Hydrolysis
- Isoquinolines
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Quinolines
- Saquinavir