Article
Associations between cytochrome P4502E1 genotype, mutagen sensitivity, cigarette smoking and susceptibility to lung cancer.
Carcinogenesis - 1 May 1997
Wu X, Shi H, Jiang H, Kemp B, Hong W K, Delclos G L, Spitz M R
Abstract excerpt
Cytochrome P4502E1 (CYP2E1) is involved in the metabolic activation of carcinogenic N-nitrosoamines. We therefore assessed the genotype frequencies of PstI or RsaI CYP2E1 restriction fragment length polymorphisms and another susceptibility marker, mutagen sensitivity, in 137 lung cancer cases (92...
Topics
- Alleles
- Case-Control Studies
- Cytochrome P-450 CYP2E1
- Disease Susceptibility
- Ethnicity
- Female
- Genotype
- Humans
- Lung Neoplasms
- Male
- Mutagens
- Polymorphism, Restriction Fragment Length