Article
Genetic susceptibility to lung cancer based on candidate genes in a sample from the Mexican Mestizo population: a case-control study.
Lung - 1 Feb 2014
Pérez-Morales R, Méndez-Ramírez I, Moreno-Macias H, Mendoza-Posadas A D, Martínez-Ramírez O C, Castro-Hernández C, Gonsebatt M E, Rubio J
Abstract excerpt
BACKGROUND: Lung cancer (LC) is the leading cause of mortality caused by neoplasias worldwide. Although cigarette smoking is the primary cause, not all smokers develop LC. Polymorphic variations in genes associated with carcinogen metabolism, DNA repair, and cell-cycle dysregulation may alter an individual risk of developing LC. A polygenic cancer model was proposed, which considers genetic susceptibility to...
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