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Article

Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens.

Cancer research - 1 Nov 1998

Le Marchand L, Sivaraman L, Pierce L, Seifried A, Lum A, Wilkens L R, Lau A F

Abstract excerpt

The dramatic shift in the pathological presentation of lung cancer [the proportional decrease in squamous cell carcinoma (SCC) and increase in adenocarcinoma (AC)] observed in the United States after the 1950s may have taken place as the result of the reduction in polycyclic aromatic hydrocarbons...

Topics

Adult
Aged
Alleles
Carcinogens
Cytochrome P-450 CYP1A1
Cytochrome P-450 CYP2E1
Genetic Predisposition to Disease
Genotype
Glutathione Transferase
Humans
Isoenzymes
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Plants, Toxic

Polycyclic Aromatic Hydrocarbons

Nicotiana

Source

Identifiers

PMID: 9809991

Genes

GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9809991-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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