Article
A case-control study of cytochrome P450 1A1, glutathione S-transferase M1, cigarette smoking and lung cancer susceptibility (Massachusetts, United States)
Cancer causes & control : CCC - 1 Jul 1997
Garcia-Closas M, Kelsey K T, Wiencke J K, Xu X, Wain J C, Christiani D C
Abstract excerpt
Cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) genetic polymorphisms are involved in the activation and detoxification of chemical carcinogens found in tobacco smoke; thus they may influence host susceptibility to lung cancer. In this study at Massachusetts General Hospital...
Topics
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Cytochrome P-450 CYP1A1
- Female
- Genetic Carrier Screening
- Genetic Predisposition to Disease
- Genotype
- Glutathione Transferase
- Homozygote
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Polymorphism, Genetic
- Risk Factors
- Smoking