Article
The role of HLA-DR-DR and HLA-DR-DP interactions in genetic susceptibility to rheumatoid arthritis.
Human immunology - 1 Mar 1996
Perdriger A, Guggenbuhl P, Chales G, Le Dantec P, Yaouanq J, Genetet B, Pawlotsky Y, Semana G
Abstract excerpt
In order to analyze the relationships between the DR and DP loci in the genetic susceptibility to RA, HLA-DRB1 and -DPB1 polymorphism was studied in 155 RA patients compared to 150 controls, using a reverse dot-blot analysis. Our data were consistent with the involvement of the amino acid in position 71 of the third hypervariable region of the DR beta 1 chain in susceptibility to the disease. The higher risk for...
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