Article
Combination of HLA-A and HLA class II alleles controls the susceptibility to rheumatoid arthritis.
Tissue antigens - 1 Dec 2001
Tsuchiya K, Kimura A, Kondo M, Nishimura Y, Sasazuki T
Abstract excerpt
Two hundred and four unrelated Japanese patients with rheumatoid arthritis (RA) were typed for HLA by serological typing and DNA typing. The serological typing revealed that frequencies of HLA-A11, DR4, DR53 and DQ4 were increased and those of DR8 and DQ1 were decreased in the patients. The DNA typing has precisely defined the disease-associated HLA class II alleles; DRBl*0405, DQAl*03 and DQBl*0401 showed...
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