Article
A possible association of HLA-DR beta 1*04 subtypes and rheumatoid arthritis of peptide binding region amino acids.
Acta microbiologica et immunologica Hungarica - 1 Jan 1996
Varga E, Samu G, Pokornyi G, Schmidt Z, Merétey K, Petri I B
Abstract excerpt
HLA-DR beta 1*04 subtypes associated with rheumatoid arthritis (RA) were studied by polymerase chain reaction with sequence specific primers and the 86th amino acid of the DR beta 1 chain was analysed in RA patients vs healthy controls. The frequency of HLA-DR beta 1*0401 and 0404/0407 alleles was significantly increased in RA patients vs the controls, HLA-DR beta 1*0401 and 0404 being the dominant variants in...
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