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Article

Identification of a modifier gene locus on chromosome 1p35-36 in familial adenomatous polyposis.

Human genetics - 1 May 1997

Dobbie Z, Heinimann K, Bishop D T, Müller H, Scott R J

Abstract excerpt

Phenotypic variability based on nonallelic heterogeneity is a characteristic feature of the dominantly inherited disease, familial adenomatous polyposis (FAP). A modifying locus, called Mom-1, which strongly influences disease expression has been mapped in the mouse model of FAP to the region of...

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Source

Identifiers

PMID: 9150735
DOI: 10.1007/s004390050423

Genes

FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9150735-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Identification of a modifier gene locus on chromosome 1p35-36 in familial adenomatous polyposis.PMID 9150735Read ↗

A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36.Semantic proximity Read ↗

Exclusion of an extracolonic disease modifier locus on chromosome 1p33-36 in a large Swiss familial adenomatous polyposis kindred.Semantic proximity Read ↗

Genetic dissection of the Mom5 modifier locus and evaluation of Mom5 candidate genes.Semantic proximity Read ↗

Explaining differences in the severity of familial adenomatous polyposis and the search for modifier genes.Semantic proximity Read ↗

Variants at the secretory phospholipase A2 (PLA2G2A) locus: analysis of associations with familial adenomatous polyposis and sporadic colorectal tumours.Semantic proximity Read ↗

Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes.Semantic proximity Read ↗

Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice.Semantic proximity Read ↗

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis.Semantic proximity Read ↗

Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice.Semantic proximity Read ↗

The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression.Semantic proximity Read ↗

Deletion of 1p loci and microsatellite instability in colorectal polyps.Semantic proximity Read ↗

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.Semantic proximity Read ↗

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