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Article

Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes.

Gut - 1 Sept 2002

Crabtree M D, Tomlinson I P M, Hodgson S V, Neale K, Phillips R K S, Houlston R S

Abstract excerpt

BACKGROUND: Familial adenomatous polyposis (FAP) is characterised by variable phenotypic expression. Part of this is attributable to a relationship between APC genotype and phenotype but there remains significant intrafamilial variation. In the Min mouse model of FAP, differences in the severity of gastrointestinal polyposis result from the action of modifier genes. AIMS: To determine whether phenotypic variation...

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Share to Adenomatous Polyposis Coli
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12171967
DOI: 10.1136/gut.51.3.420
PMCID: PMC1773342

Genes

FAP
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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