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Article

Exclusion of an extracolonic disease modifier locus on chromosome 1p33-36 in a large Swiss familial adenomatous polyposis kindred.

European journal of human genetics : EJHG - 1 May 2004

Plasilova M, Russell A M, Wanner A, Wolf A, Dobbie Z, Müller H J, Heinimann K

Abstract excerpt

Familial adenomatous polyposis (FAP), an autosomal dominantly inherited colorectal cancer predisposition syndrome, displays considerable inter- and intrafamilial phenotypic heterogeneity, which represents a major problem in genetic counselling of APC mutation carriers. The Min mouse model indicated a putative disease modifier locus on chromosome 4, which is syntenic to human chromosome 1p35-36. This finding was...

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Source

Identifiers

PMID: 14735163
DOI: 10.1038/sj.ejhg.5201157

Genes

FAP
APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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