Article
Epistatic interaction between alpha- and gamma-adducin influences peripheral and central pulse pressures in white Europeans.
Journal of hypertension - 1 May 2005
Cwynar Marcin, Staessen Jan A, Tichá Milena, Nawrot Tim, Citterio Lorena, Kuznetsova Tatiana, Wojciechowska Wiktoria, Stolarz Katarzyna, Filipovský Jan, Kawecka-Jaszcz Kalina, Grodzicki Tomasz, Struijker-Boudier Harry A, Thijs Lutgarde, Van Bortel Luc M, Bianchi Giuseppe
Abstract excerpt
BACKGROUND: Adducin is a membrane skeleton protein consisting of alpha- and beta- or alpha- and gamma-subunits. Mutations in alpha- and beta-adducin are associated with hypertension. In the European Project on Genes in Hypertension, we investigated whether polymorphisms in the genes encoding alpha-adducin (Gly460Trp), beta-adducin (C1797T) and gamma-adducin (A386G), alone or in combination, affected pulse...
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