Article
Human alpha-adducin gene, blood pressure, and sodium metabolism.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 1998
Kamitani A, Wong Z Y, Fraser R, Davies D L, Connor J M, Foy C J, Watt G C, Harrap S B
Abstract excerpt
The adducin genes contribute significantly to population variation in rat blood pressure and cell membrane sodium transport. The 460Trp mutation of the human alpha-adducin gene has been associated with hypertension, in particular hypertension sensitive to sodium restriction. We studied the relationship between the 460Trp mutation and population variation in blood pressure and sodium metabolism. From 603 Scottish...
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