Article
Low-renin hypertension, altered sodium homeostasis, and an alpha-adducin polymorphism.
Hypertension (Dallas, Tex. : 1979) - 1 Feb 2002
Grant Frederick D, Romero Jose R, Jeunemaitre Xavier, Hunt Steven C, Hopkins Paul N, Hollenberg Norman H, Williams Gordon H
Abstract excerpt
Defining the genetic basis of common forms of human essential hypertension is most informative when correlated with physiological mechanisms that underlie blood pressure regulation. A polymorphism of the alpha-adducin gene as been associated with elevated blood pressure in the rat, but previous studies of the 460Trp polymorphism of the human alpha-adducin gene have not clearly identified an association with...
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