Article
Alpha Adducin G460T Variant is a Risk Factor for Hypertension in Tunisian Population.
Clinical laboratory - 1 Jan 2016
Soualmia Hayet, Ben Romdhane Abir, Midani Fatma, Kallel Amani, Jemaa Riadh, Feki Moncef, Kaabachi Naziha
Abstract excerpt
BACKGROUND: Adducin is a membrane cytoskeletal protein, consisting of three subunits: α, β, and γ subunits encoded by three different genes (ADD1, ADD2, ADD3). A specific mutation G460T of the α-adducin gene (ADD1) is associated with high renal tubular sodium reabsorption. This mutation is associated with salt sensitivity and may influence the risk of hypertension. In this study, we investigated the relationship...
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