Linkage but lack of association for blood pressure and the alpha-adducin locus in normotensive twins.

doi:10.1097/00004872-199917100-00011

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Article

Linkage but lack of association for blood pressure and the alpha-adducin locus in normotensive twins.

Journal of hypertension - 1 Oct 1999

Busjahn A, Aydin A, von Treuenfels N, Faulhaber H D, Gohlke H R, Knoblauch H, Schuster H, Luft F C

Abstract excerpt

BACKGROUND: alpha-adducin is a cytoskeletal protein involved with sodium-pump activity in the renal tubule. The alpha-adducin gene locus has been linked to hypertension and a polymorphism identified which is associated with hypertension; however, the role of the alpha-adducin gene locus in normal blood pressure regulation is not defined. We performed a combined linkage and association study in normotensive...

Topics

Adolescent
Adult
Blood Pressure
Calmodulin-Binding Proteins
Cytoskeletal Proteins
Genetic Linkage
Heart
Humans
Mutation
Polymorphism, Genetic
Twins

Source

Open in PubMed

Identifiers

PMID: 10526904
DOI: 10.1097/00004872-199917100-00011

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