Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between hypertension and variation in the alpha- and beta-adducin genes in a white population.

Kidney international - 1 Dec 2002

Wang Ji-Guang, Staessen Jan A, Barlassina Cristina, Fagard Robert, Kuznetsova Tatiana, Struijker-Boudier Harry A, Zagato Laura, Citterio Lorena, Messaggio Elisabetta, Bianchi Giuseppe

Abstract excerpt

BACKGROUND: The substitution of tryptophan for glycine at amino acid 460 (Gly460Trp polymorphism) of the alpha-subunit of the heterodimeric cytoskeleton protein adducin increases renal sodium reabsorption and may be involved in the pathophysiology of essential hypertension. In the present study, we investigated in multivariate analyses whether the risk of hypertension was associated with the C1797T polymorphism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Calmodulin-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Hypertension, Renal

Share to Linkage Disequilibrium

Share to Polymorphism, Genetic

Share to Sex Distribution

Source

Identifiers

PMID: 12427140
DOI: 10.1046/j.1523-1755.2002.00691.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between hypertension and variation in the alpha- and beta-adducin genes in a white population.PMID 12427140Read ↗

Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension.Semantic proximity Read ↗

Association between the alpha-adducin gene and hypertension in the HyperGEN Study.Semantic proximity Read ↗

Epistatic interaction between alpha- and gamma-adducin influences peripheral and central pulse pressures in white Europeans.Semantic proximity Read ↗

Alpha-adducin Gly460Trp polymorphism and hypertension risk: a meta-analysis of 22 studies including 14303 cases and 15961 controls.Semantic proximity Read ↗

Adducin and hypertension.Semantic proximity Read ↗

Alpha-adducin gene polymorphism and cardiovascular phenotypes in a general population.Semantic proximity Read ↗

Polymorphism of alpha-adducin in Japanese patients with essential hypertension.Semantic proximity Read ↗

Pharmacogenomics and pharmacogenetics of hypertension: update and perspectives--the adducin paradigm.Semantic proximity Read ↗

beta-Adducin polymorphisms, blood pressure, and sodium excretion in three European populations.Semantic proximity Read ↗

Lack of association between the alpha-adducin locus and essential hypertension in the Japanese population.Semantic proximity Read ↗

Alpha Adducin G460T Variant is a Risk Factor for Hypertension in Tunisian Population.Semantic proximity Read ↗

Association of the alpha-adducin locus with essential hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.