Article
Functional haploinsufficiency of the human homeobox gene MSX2 causes defects in skull ossification.
Nature genetics - 1 Apr 2000
Wilkie A O, Tang Z, Elanko N, Walsh S, Twigg S R, Hurst J A, Wall S A, Chrzanowska K H, Maxson R E
Abstract excerpt
The genetic analysis of congenital skull malformations provides insight into normal mechanisms of calvarial osteogenesis. Enlarged parietal foramina (PFM) are oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month. PFM are usually asymptomatic, but may be associated with headache, scalp defects and structural or...
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