Article
Impairment of pupillary responses and optokinetic nystagmus in the mGluR6-deficient mouse.
Neuropharmacology - 1 Feb 1997
Iwakabe H, Katsuura G, Ishibashi C, Nakanishi S
Abstract excerpt
Retinal bipolar cells receive glutamatergic transmission from photoreceptors and mediate a key process in segregating visual signals into ON-center and OFF-center pathways. The segregation of ON responses involves a G protein-coupled metabotropic glutamate receptor (mGluR). The mGluR6 subtype is expressed restrictedly at the postsynaptic site of retinal ON-bipolar cells. Ablation of mGluR6 in the ON-bipolar cells...
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