Article
Allelic variance between GRM6 mutants, Grm6nob3 and Grm6nob4 results in differences in retinal ganglion cell visual responses.
The Journal of physiology - 15 Sept 2008
Maddox Dennis M, Vessey Kirstan A, Yarbrough Gary L, Invergo Brandon M, Cantrell Donald R, Inayat Samsoon, Balannik Victoria, Hicks Wanda L, Hawes Norman L, Byers Shannon, Smith Richard S, Hurd Ron, Howell Douglas, Gregg Ronald G, Chang Bo, Naggert Jürgen K, Troy John B, Pinto Lawrence H, Nishina Patsy M, McCall Maureen A
Abstract excerpt
An electroretinogram (ERG) screen identified a mouse with a normal a-wave but lacking a b-wave, and as such it was designated no b-wave3 (nob3). The nob3 phenotype mapped to chromosome 11 in a region containing the metabotropic glutamate receptor 6 gene (Grm6). Sequence analyses of cDNA identified a splicing error in Grm6, introducing an insertion and an early stop codon into the mRNA of affected mice (designated...
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