Article
The nob2 mouse, a null mutation in Cacna1f: anatomical and functional abnormalities in the outer retina and their consequences on ganglion cell visual responses.
Visual neuroscience - 1 Jan 2000
Chang Bo, Heckenlively John R, Bayley Philippa R, Brecha Nicholas C, Davisson Muriel T, Hawes Norm L, Hirano Arlene A, Hurd Ronald E, Ikeda Akihiro, Johnson Britt A, McCall Maureen A, Morgans Catherine W, Nusinowitz Steve, Peachey Neal S, Rice Dennis S, Vessey Kirstan A, Gregg Ronald G
Abstract excerpt
Glutamate release from photoreceptor terminals is controlled by voltage-dependent calcium channels (VDCCs). In humans, mutations in the Cacna1f gene, encoding the alpha1F subunit of VDCCs, underlie the incomplete form of X-linked congenital stationary night blindness (CSNB2). These mutations impair synaptic transmission from rod and cone photoreceptors to bipolar cells. Here, we report anatomical and functional...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.