Article
ON pathway mutations increase susceptibility to form-deprivation myopia.
Experimental eye research - 1 Aug 2015
Chakraborty Ranjay, Park Han Na, Hanif Adam M, Sidhu Curran S, Iuvone P Michael, Pardue Machelle T
Abstract excerpt
The ON pathway mutation in nob mice is associated with altered refractive development, and an increased susceptibility to form-deprivation (FD) myopia. In this study, we used mGluR6-/- mice, another ON pathway mutant, to determine whether the nob phenotype was due to the Nyx mutation or abnormal ON pathway transmission. Refractive development under a normal visual environment for mGluR6-/- and age-matched...
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