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Article

Regulation of the Murine Nfatc1 Gene by NFATc2

1 Mar 2002

Abstract excerpt

NFAT proteins play a key role in the inducible expression of cytokine genes in T lymphocytes. NFATc1 and NFATc2 are the predominant NFAT family members in the peripheral immune system. NFATc2 is found abundantly in the cytoplasm of resting T cells, whereas Nfatc1 expression is induced during T cell activation. To investigate Nfatc1 regulation, we characterized the structure of the murine Nfatc1 gene and its...

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PMID: 11786533
DOI: 10.1074/jbc.m107068200

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