Article
PTD-mediated intracellular delivery of mutant NFAT minimum DNA binding domain inhibited the proliferation of T cells.
International immunopharmacology - 1 Mar 2014
Liu Xia, Zhao Qianqian, Peng Xin, Xia Sheng, Shen Weihong, Zong Yangyong, Cheng Jing, Wu Weijiang, Zhang Miaomiao, Du Fengyi, Xu Wenrong, Qian Hui, Shao Qixiang
Abstract excerpt
The nuclear factor of activated T cell (NFAT) family of calcium-regulated transcription factors plays a key role in the development and function of the immune system. Calcineurin, a protein phosphatase, activates NFAT by dephosphorylation. The activated NFAT is translocated into the nucleus, where it up-regulates the expression of interleukin 2 (IL-2) and other target genes. Calcineurin inhibitors such as...
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