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Article

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

7 Nov 2005

Abstract excerpt

NFATc1 and NFATc2 are functionally redundant in the immune system, but it was suggested that NFATc1 is required exclusively for differentiation of osteoclasts in the skeletal system. Here we provide genetic evidence that NFATc1 is essential for osteoclast differentiation in vivo by adoptive transfer of NFATc1(-/-) hematopoietic stem cells to osteoclast-deficient Fos(-/-) mice, and by Fos(-/-) blastocyst...

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PMID: 16275763
DOI: 10.1084/jem.20051150

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