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Article

Histone-like protein HU as a specific transcriptional regulator: co-factor role in repression of gal transcription by GAL repressor.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Feb 1996

Aki T, Choy H E, Adhya S

Abstract excerpt

BACKGROUND: Transcription initiation from the two overlapping promoters of the gal operon in Escherichia coli is negatively regulated by binding of Gal repressor (GalR) to bipartite operators, which encompass the promoters. Coordinated repression of the two promoters requires GalR binding to both operators. In a purified system, GalR, nevertheless, fails to show the coordinated repression, predicting the...

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Source

Identifiers

PMID: 9140062
DOI: 10.1046/j.1365-2443.1996.d01-236.x

Genes

GAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone-like protein HU as a specific transcriptional regulator: co-factor role in repression of gal transcription by GAL repressor.PMID 9140062Read ↗

Three-stage regulation of the amphibolic gal operon: from repressosome to GalR-free DNA.Semantic proximity Read ↗

Operator-bound GalR dimers close DNA loops by direct interaction: tetramerization and inducer binding.Semantic proximity Read ↗

Recruitment of HU by piggyback: a special role of GalR in repressosome assembly.Semantic proximity Read ↗

Coordination of genomic structure and transcription by the main bacterial nucleoid-associated protein HU.Semantic proximity Read ↗

Repression and activation of promoter-bound RNA polymerase activity by Gal repressor.Semantic proximity Read ↗

The non-inducible nature of super-repressors of the gal operon in Escherichia coli.Semantic proximity Read ↗

Gal repressosome contains an antiparallel DNA loop.Semantic proximity Read ↗

In vitro repression of the gal promoters by GalR and HU depends on the proper helical phasing of the two operators.Semantic proximity Read ↗

HU and IHF: similarities and differences. In Escherichia coli, the lack of HU is not compensated for by IHF.Semantic proximity Read ↗

The histone-like protein HU does not obstruct movement of T7 RNA polymerase in Escherichia coli cells but stimulates its activity.Semantic proximity Read ↗

The transcriptional regulator GalR self-assembles to form highly regular tubular structures.Semantic proximity Read ↗

Genetic analysis of GalR tetramerization in DNA looping during repressosome assembly.Semantic proximity Read ↗

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