Article
Genetic analysis of GalR tetramerization in DNA looping during repressosome assembly.
The Journal of biological chemistry - 6 Sept 2002
Geanacopoulos Mark, Adhya Sankar
Abstract excerpt
The Gal repressosome is a nucleoprotein complex consisting of 2 GalR dimers, 1 HU, and 1 DNA loop, which represses the transcription of the gal operon. We have adopted a structure-based genetic approach to complement ongoing physical studies of the complex. Homology-based and subsequent alanine-s...
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