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Article

Epigenetic modulation of the IGF2/H19 imprinted domain in human embryonic and extra-embryonic compartments and its possible role in fetal growth restriction.

Epigenetics - 16 May 2010

Tabano Silvia, Colapietro Patrizia, Cetin Irene, Grati Francesca R, Zanutto Susanna, Mandò Chiara, Antonazzo Patrizio, Pileri Paola, Rossella Franca, Larizza Lidia, Sirchia Silvia M, Miozzo Monica

Abstract excerpt

Genomic imprinting, resulting in parent-of-origin-dependent gene expression, is mainly achieved by DNA methylation. IGF2 and H19, belonging to the same cluster of imprinted genes and regulated by ICR1, DMR2 and H19 promoter elements, play a major role in fetal/placental growth. Using quantitative approaches, we explored the epigenetic modulation of IGF2/H19 during human development in 60 normal and 66 idiopathic...

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Identifiers

PMID: 20418667
DOI: 10.4161/epi.5.4.11637

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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