Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The paternally imprinted DLK1-GTL2 locus is differentially methylated in embryonal and alveolar rhabdomyosarcomas.

International journal of oncology - 1 Jan 2014

Schneider Gabriela, Bowser Mark J, Shin Dong-Myung, Barr Frederic G, Ratajczak Mariusz Z

Abstract excerpt

Parental imprinting of differentially methylated regions (DMRs) contributes to appropriate expression of several developmentally important genes from paternally or maternally derived chromosomes. Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and is associated with altered expression of certain parentally imprinted genes. As previously reported, RMS cells display loss of imprinting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Binding Proteins
Share to Chromosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Expression Regulation, Neoplastic

Share to Genomic Imprinting

Share to Intercellular Signaling Peptides and Proteins

Share to Rhabdomyosarcoma, Embryonal

Share to RNA, Long Noncoding

Source

Open in PubMed Open full text

Identifiers

PMID: 24173021
DOI: 10.3892/ijo.2013.2153
PMCID: PMC3867365

Genes

DLK1
IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The paternally imprinted DLK1-GTL2 locus is differentially methylated in embryonal and alveolar rhabdomyosarcomas.PMID 24173021Read ↗

Epigenetic analysis of the Dlk1-Gtl2 imprinted domain on mouse chromosome 12: implications for imprinting control from comparison with Igf2-H19Semantic proximity Read ↗

Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene.Semantic proximity Read ↗

Activation of an imprinted allele of the insulin-like growth factor II gene implicated in rhabdomyosarcoma.Semantic proximity Read ↗

Epigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms' tumourSemantic proximity Read ↗

Imprinting status of DLK1 gene in brain tumors and lymphomas.Semantic proximity Read ↗

Expression and parental imprinting of the H19 gene in human rhabdomyosarcoma.Semantic proximity Read ↗

At Least Ten Genes Define the Imprinted Dlk1-Dio3 Cluster on Mouse Chromosome 12qF1Semantic proximity Read ↗

Imprinting, expression, and localisation of DLK1 in Wilms tumours.Semantic proximity Read ↗

Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinomaSemantic proximity Read ↗

Molecular mechanisms regulating phenotypic outcome in paternal and maternal uniparental disomy for chromosome 14.Semantic proximity Read ↗

Characterization of the imprinting signature of mouse embryo fibroblasts by RNA deep sequencing.Semantic proximity Read ↗

IGF2: epigenetic regulation and role in development and disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.