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Article

Dissociation of IGF2 and H19 imprinting in human brain.

Brain research - 9 Nov 1998

Pham N V, Nguyen M T, Hu J F, Vu T H, Hoffman A R

Abstract excerpt

The human IGF2 and H19 genes are imprinted in most normal tissues. Alterations of genomic imprinting or loss of imprinting (LOI) have been observed in a number of malignant tumors. Although LOI has been linked to tumorigenesis, loss of IGF2 imprinting has also been observed in choroid plexus and leptomeninges in normal mouse brain. We have therefore analyzed the allelic expression of both IGF2 and H19 in human...

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PMID: 9813220
DOI: 10.1016/s0006-8993(98)00783-5

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Dissociation of IGF2 and H19 imprinting in human brain.PMID 9813220Read ↗

Genomic imprinting in the rat: linkage of Igf2 and H19 genes and opposite parental allele-specific expression during embryogenesis.Semantic proximity Read ↗

Overlapping patterns of IGF2 and H19 expression during human development: biallelic IGF2 expression correlates with a lack of H19 expression.Semantic proximity Read ↗

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IGF2 but not H19 shows loss of imprinting in human glioma.Semantic proximity Read ↗

Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes.Semantic proximity Read ↗

H19 is imprinted in the choroid plexus and leptomeninges of the mouse foetus.Semantic proximity Read ↗

Polymorphic functional imprinting of the human IGF2 gene among individuals, in blood cells, is associated with H19 expression.Semantic proximity Read ↗

Quantitative allele-specific expression and DNA methylation analysis of H19, IGF2 and IGF2R in the human placenta across gestation reveals H19 imprinting plasticity.Semantic proximity Read ↗

Symmetric and asymmetric DNA methylation in the human IGF2-H19 imprinted region.Semantic proximity Read ↗

Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastomaSemantic proximity Read ↗

Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesisSemantic proximity Read ↗

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