Aminolevulinic acid dehydratase genotype mediates plasma levels of the neurotoxin, 5-aminolevulinic acid, in lead-exposed workers.

doi:10.1002/(sici)1097-0274(199707)32:1<15::aid-ajim2>3.0.co;2-q

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Article

Aminolevulinic acid dehydratase genotype mediates plasma levels of the neurotoxin, 5-aminolevulinic acid, in lead-exposed workers.

American journal of industrial medicine - 1 Jul 1997

Sithisarankul P, Schwartz B S, Lee B K, Kelsey K T, Strickland P T

Abstract excerpt

The first intermediate substrate in the heme synthetic pathway, 5-aminolevulinic acid (ALA), is neurotoxic in animal models and may be responsible for some of the adverse neurologic outcomes in lead poisoning and porphyria in adult humans. ALA is a substrate for the enzyme aminolevulinic acid deh...

Topics

Adult
Aminolevulinic Acid
Genotype
Humans
Korea
Lead
Male
Middle Aged
Occupational Exposure
Porphobilinogen Synthase

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