Article
Interaction of blood lead and delta-aminolevulinic acid dehydratase genotype on markers of heme synthesis and sperm production in lead smelter workers.
Environmental health perspectives - 1 Apr 1998
Alexander B H, Checkoway H, Costa-Mallen P, Faustman E M, Woods J S, Kelsey K T, van Netten C, Costa L G
Abstract excerpt
The gene that encodes gamma-aminolevulinic acid dehydratase (ALAD) has a polymorphism that may modify lead toxicokinetics and ultimately influence individual susceptibility to lead poisoning. To evaluate the effect of the ALAD polymorphism on lead-mediated outcomes, a cross-sectional study of male employees from a lead-zinc smelter compared associations between blood lead concentration and markers of heme...
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